Assay Detail
Binding
CHEMBL675709
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Displacement of [3H]- spiperone radioligand binding at the dopamine binding site of rat caudate
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.35 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1255588 | — | — | 1 | 9.70 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.70 |
| CHEMBL368578 | — | — | 1 | 8.15 |
| CHEMBL415761 | — | — | 1 | 7.96 |
| CHEMBL175508 | — | — | 1 | 7.96 |
| CHEMBL368475 | — | — | 1 | 7.92 |
| CHEMBL424967 | — | — | 1 | 7.77 |
| CHEMBL368357 | — | — | 1 | 7.70 |
| CHEMBL178376 | — | — | 1 | 7.57 |
| CHEMBL176365 | — | — | 1 | 7.50 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 1 | 7.20 |
| CHEMBL175154 | — | — | 1 | 6.94 |
| CHEMBL368413 | — | — | 1 | 6.68 |
| CHEMBL174649 | — | — | 1 | 4.36 |
| CHEMBL442783 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1255588 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL267930 | SPIPERONE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL368578 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL415761 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL175508 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL368475 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL424967 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL368357 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL178376 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL176365 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL175154 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL368413 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL174649 | — | Ki | = | 43500.0 | nM | 4.36 |
| CHEMBL442783 | — | Ki | = | 80000.0 | nM | 4.10 |