Assay Detail
Binding
CHEMBL675834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranes
11
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.65 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333794 | — | — | 4 | 8.70 |
| CHEMBL333795 | — | — | 1 | 8.66 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.51 |
| CHEMBL332546 | — | — | 1 | 7.64 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 7.55 |
| CHEMBL330997 | — | — | 1 | 7.54 |
| CHEMBL332337 | — | — | 1 | 7.48 |
| CHEMBL121653 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333794 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL333795 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL333794 | — | IC50 | = | 4.65 | nM | 8.33 |
| CHEMBL332546 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 27.9 | nM | 7.55 |
| CHEMBL330997 | — | IC50 | = | 28.9 | nM | 7.54 |
| CHEMBL332337 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL121653 | — | IC50 | = | 59.6 | nM | 7.22 |
| CHEMBL333794 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL333794 | — | IC50 | = | 1240.0 | nM | 5.91 |