Assay Detail
Binding
CHEMBL675835
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In vitro affinity to dopamine receptor using [3H]HPD as radioligand in rat striatal membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
6- and 8-hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyrans. Dopamine agonists with autoreceptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.22 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38428 | — | — | 1 | 8.00 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.57 |
| CHEMBL69414 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38428 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL69414 | — | IC50 | = | 800.0 | nM | 6.10 |