Assay Detail
Binding
CHEMBL675837
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In vitro binding affinity towards dopamine receptor was determined in rat striatal membrane using [3H]spiroperidol as the radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and central dopaminergic activities of (+/-)-hexahydro-7H-indolo[3,4-gh][1,4]benzoxazine derivatives [(+/-)-9-oxaergolines].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.24 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1275 | PERGOLIDE MESYLATE | 4.0 | 1 | 7.16 |
| CHEMBL333795 | — | — | 1 | 7.16 |
| CHEMBL347326 | — | — | 1 | 6.60 |
| CHEMBL148600 | — | — | 1 | 6.22 |
| CHEMBL330997 | — | — | 1 | 6.10 |
| CHEMBL147244 | — | — | 1 | 6.00 |
| CHEMBL359414 | — | — | 1 | 5.35 |
| CHEMBL121653 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1275 | PERGOLIDE MESYLATE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL333795 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL347326 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL148600 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL330997 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL147244 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL359414 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL121653 | — | IC50 | = | 5000.0 | nM | 5.30 |