Assay Detail
Binding
CHEMBL675840
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Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranes
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.73 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6066838 | — | — | 1 | 8.70 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.18 |
| CHEMBL64348 | — | — | 1 | 7.30 |
| CHEMBL27429 | — | — | 1 | 7.29 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 7.07 |
| CHEMBL13647 | BMY-7378 | — | 1 | 7.04 |
| CHEMBL60322 | — | — | 1 | 7.04 |
| CHEMBL64803 | — | — | 1 | 6.96 |
| CHEMBL59638 | — | — | 1 | 6.96 |
| CHEMBL292705 | — | — | 1 | 6.92 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.92 |
| CHEMBL305121 | — | — | 1 | 6.63 |
| CHEMBL303810 | — | — | 1 | 6.54 |
| CHEMBL62967 | — | — | 1 | 6.46 |
| CHEMBL64084 | — | — | 1 | 6.41 |
| CHEMBL296254 | — | — | 1 | 6.37 |
| CHEMBL440302 | — | — | 1 | 6.37 |
| CHEMBL292730 | — | — | 1 | 6.27 |
| CHEMBL60733 | — | — | 1 | 6.24 |
| CHEMBL62418 | — | — | 1 | 6.20 |
| CHEMBL61330 | — | — | 1 | 6.19 |
| CHEMBL64228 | — | — | 1 | 6.18 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.05 |
| CHEMBL302865 | — | — | 1 | 6.03 |
| CHEMBL60154 | — | — | 1 | 6.02 |
| CHEMBL293962 | — | — | 1 | - |
| CHEMBL57364 | — | — | 1 | - |
| CHEMBL61272 | — | — | 1 | - |
| CHEMBL431750 | — | — | 1 | - |
| CHEMBL293968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6066838 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL64348 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL27429 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL13647 | BMY-7378 | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL60322 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL64803 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL59638 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL292705 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL305121 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL303810 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL62967 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL64084 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL296254 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL440302 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL292730 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL60733 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL62418 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL61330 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL64228 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL302865 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL60154 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL60842 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL303078 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL58172 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL27314 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL284092 | GEPIRONE | IC50 | > | 1000.0 | nM | - |
| CHEMBL59643 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL293968 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL431750 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL61272 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL57364 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL293962 | — | IC50 | > | 1000.0 | nM | - |