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Assay Detail

CHEMBL675842

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against [3H]NPA binding (0.45) to dopamine receptors in striata of female wistar rats
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Dopamine receptor (CHEMBL2093868)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Resolution of 5,6-dihydroxy-2-(N,N-di-n-propylamino)tetralin in relation to the structural and stereochemical requirements for centrally acting dopamine agonists.
Grol CJ, Jansen LJ, Rollema H.
J Med Chem (1985) 28 : 679 -683
PubMed 4039369 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.40 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL11845 1 8.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL11845 IC50 = 4.0 nM 8.40