Assay Detail
Functional
CHEMBL675844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against [3H]- spiperone binding to Dopamine receptor at 10 mg/kg
9
Total Activities
8
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analogue of apomorphine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.44 | 6.96 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSE | DOSE | 10.0 | mg.kg-1 | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.96 |
| CHEMBL146824 | — | — | 1 | 6.51 |
| CHEMBL3143962 | — | — | 2 | 5.54 |
| CHEMBL3143955 | — | — | 1 | 5.33 |
| CHEMBL357911 | — | — | 1 | 5.16 |
| CHEMBL3216394 | — | — | 1 | 4.37 |
| CHEMBL3216862 | — | — | 1 | 4.24 |
| CHEMBL3215543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL146824 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3143962 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3143955 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL357911 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3216394 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3216862 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL3143962 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3215543 | — | IC50 | > | 100000.0 | nM | - |