Assay Detail
Binding
CHEMBL675845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency of inhibiting 10 pM [125I]-RTI-55 binding to dopamine receptor in rat striatal membranes
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.65 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54134 | — | — | 1 | 8.57 |
| CHEMBL300620 | — | — | 2 | 7.96 |
| CHEMBL52154 | — | — | 1 | 7.47 |
| CHEMBL50159 | — | — | 1 | 7.04 |
| CHEMBL53342 | — | — | 1 | 6.94 |
| CHEMBL904 | DEXMETHYLPHENIDATE HYDROCHLORIDE | 4.0 | 1 | 6.79 |
| CHEMBL298583 | — | — | 1 | 5.99 |
| CHEMBL51371 | — | — | 1 | 5.68 |
| CHEMBL301775 | — | — | 1 | 5.56 |
| CHEMBL52213 | — | — | 1 | 5.19 |
| CHEMBL51101 | — | — | 1 | 5.13 |
| CHEMBL50570 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54134 | — | IC50 | = | 2.67 | nM | 8.57 |
| CHEMBL300620 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL300620 | — | IC50 | = | 33.9 | nM | 7.47 |
| CHEMBL52154 | — | IC50 | = | 33.8 | nM | 7.47 |
| CHEMBL50159 | — | IC50 | = | 91.2 | nM | 7.04 |
| CHEMBL53342 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL904 | DEXMETHYLPHENIDATE HYDROCHLORIDE | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL298583 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL51371 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL301775 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL52213 | — | IC50 | = | 6470.0 | nM | 5.19 |
| CHEMBL51101 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL50570 | — | IC50 | > | 1000.0 | nM | - |