Assay Detail
Binding
CHEMBL675847
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Potency of inhibiting [3H]WIN-35428 binding to dopamine receptor in rat striatal membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.82 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54134 | — | — | 1 | 8.28 |
| CHEMBL50159 | — | — | 1 | 7.69 |
| CHEMBL53342 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54134 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL50159 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL53342 | — | IC50 | = | 33.0 | nM | 7.48 |