Assay Detail
Binding
CHEMBL675848
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Relative affinity for dopamine receptor by displacement of [3H]spiroperidol (2.2 nM) from (in vitro) dopamine binding sites in rat caudate nuclei
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.97 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7617 | — | — | 1 | 7.41 |
| CHEMBL275696 | — | — | 1 | 6.47 |
| CHEMBL7430 | — | — | 1 | 6.17 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 6.12 |
| CHEMBL7821 | — | — | 1 | 6.09 |
| CHEMBL7828 | ISOLOXAPINE | — | 1 | 5.61 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 5.37 |
| CHEMBL266723 | — | — | 1 | 4.49 |
| CHEMBL269396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7617 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL275696 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL7430 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL415300 | ISOCLOZAPINE | IC50 | = | 758.0 | nM | 6.12 |
| CHEMBL7821 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL7828 | ISOLOXAPINE | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL266723 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL269396 | — | IC50 | > | 10000.0 | nM | - |