Assay Detail
Binding
CHEMBL675850
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for Dopamine receptor activity by the inhibition against spiroperidol binding to rat caudate tissue.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.73 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.27 |
| CHEMBL1467585 | — | — | 1 | 4.47 |
| CHEMBL542700 | — | — | 1 | 4.46 |
| CHEMBL2093929 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL1467585 | — | IC50 | = | 33860.0 | nM | 4.47 |
| CHEMBL542700 | — | IC50 | = | 34430.0 | nM | 4.46 |
| CHEMBL2093929 | — | IC50 | = | 197400.0 | nM | - |