Assay Detail
Binding
CHEMBL675903
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Inhibitory activity against Dopamine transporter using 0.5 nM [3H]WIN-35428 as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.66 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790051 | — | — | 1 | 7.64 |
| CHEMBL3085557 | — | — | 1 | 7.55 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
| CHEMBL21362 | — | — | 1 | 6.26 |
| CHEMBL3084343 | — | — | 1 | 5.90 |
| CHEMBL610898 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790051 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3085557 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL21362 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3084343 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL610898 | — | IC50 | = | 2860.0 | nM | 5.54 |