Assay Detail
Binding
CHEMBL675909
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Inhibitory activity against radioligand [3H]WIN-35428 binding at the dopamine transporter
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.34 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82027 | — | — | 1 | 8.77 |
| CHEMBL123058 | — | — | 2 | 8.71 |
| CHEMBL3084336 | — | — | 2 | 7.90 |
| CHEMBL1790051 | — | — | 1 | 7.64 |
| CHEMBL3085511 | — | — | 2 | 7.55 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82027 | — | IC50 | = | 1.71 | nM | 8.77 |
| CHEMBL123058 | — | IC50 | = | 1.96 | nM | 8.71 |
| CHEMBL3084336 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL1790051 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3085511 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL123058 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL3084336 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3085511 | — | IC50 | = | 1270.0 | nM | 5.90 |