Assay Detail
Binding
CHEMBL675914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Endothelin-converting enzyme of guinea pig lung membrane
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Highly potent and selective inhibitors of endothelin converting enzyme
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.47 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22957 | — | — | 1 | 7.60 |
| CHEMBL282660 | — | — | 1 | 7.40 |
| CHEMBL280152 | — | — | 1 | 7.19 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 7.00 |
| CHEMBL278076 | — | — | 1 | 6.80 |
| CHEMBL427799 | — | — | 1 | 6.60 |
| CHEMBL25221 | — | — | 1 | 6.41 |
| CHEMBL23598 | — | — | 1 | 6.30 |
| CHEMBL280907 | — | — | 1 | 6.30 |
| CHEMBL435561 | — | — | 1 | 6.10 |
| CHEMBL262783 | — | — | 2 | 5.89 |
| CHEMBL18461 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22957 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL282660 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL280152 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL278076 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL427799 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL25221 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL23598 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL280907 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL435561 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL262783 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL18461 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL262783 | — | IC50 | = | 6000.0 | nM | 5.22 |