Assay Detail
Binding
CHEMBL675992
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In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D4 using FLIPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.17 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.82 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.57 |
| CHEMBL77395 | — | — | 1 | 7.66 |
| CHEMBL440687 | ABT-724 | — | 1 | 7.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL59 | DOPAMINE | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL77395 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL440687 | ABT-724 | EC50 | = | 23.2 | nM | 7.63 |