Assay Detail
Binding
CHEMBL676067
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Inhibitory activity against epidermal growth factor receptor (EGFR)
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.19 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116595 | — | — | 1 | 6.40 |
| CHEMBL56543 | — | — | 1 | 6.30 |
| CHEMBL293749 | — | — | 1 | 6.21 |
| CHEMBL432428 | — | — | 1 | 6.19 |
| CHEMBL119987 | — | — | 1 | 6.15 |
| CHEMBL53898 | — | — | 1 | 6.15 |
| CHEMBL326318 | — | — | 1 | 6.05 |
| CHEMBL326100 | — | — | 1 | 6.00 |
| CHEMBL56731 | — | — | 1 | 5.90 |
| CHEMBL143212 | — | — | 1 | 5.77 |
| CHEMBL333454 | — | — | 1 | 5.76 |
| CHEMBL56219 | — | — | 1 | 5.68 |
| CHEMBL55979 | — | — | 1 | 5.60 |
| CHEMBL143805 | — | — | 1 | 5.52 |
| CHEMBL119156 | — | — | 1 | 5.47 |
| CHEMBL296407 | — | — | 1 | 5.35 |
| CHEMBL440298 | — | — | 1 | 5.30 |
| CHEMBL56393 | — | — | 1 | 5.30 |
| CHEMBL55204 | — | — | 1 | 5.29 |
| CHEMBL118205 | — | — | 1 | 5.28 |
| CHEMBL417941 | — | — | 1 | 5.23 |
| CHEMBL59145 | — | — | 1 | 5.18 |
| CHEMBL122522 | — | — | 1 | 5.17 |
| CHEMBL118321 | — | — | 1 | 5.10 |
| CHEMBL324030 | — | — | 1 | 5.06 |
| CHEMBL55360 | — | — | 1 | 4.99 |
| CHEMBL56879 | — | — | 1 | 4.96 |
| CHEMBL56542 | — | — | 1 | 4.92 |
| CHEMBL56132 | — | — | 1 | 4.85 |
| CHEMBL331026 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116595 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL56543 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL293749 | — | IC50 | = | 616.6 | nM | 6.21 |
| CHEMBL432428 | — | IC50 | = | 645.65 | nM | 6.19 |
| CHEMBL119987 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL53898 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL326318 | — | IC50 | = | 891.25 | nM | 6.05 |
| CHEMBL326100 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL56731 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL143212 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL333454 | — | IC50 | = | 1737.8 | nM | 5.76 |
| CHEMBL56219 | — | IC50 | = | 2089.3 | nM | 5.68 |
| CHEMBL55979 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL143805 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL119156 | — | IC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL296407 | — | IC50 | = | 4466.84 | nM | 5.35 |
| CHEMBL440298 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL56393 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL55204 | — | IC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL118205 | — | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL417941 | — | IC50 | = | 5888.44 | nM | 5.23 |
| CHEMBL59145 | — | IC50 | = | 6606.93 | nM | 5.18 |
| CHEMBL122522 | — | IC50 | = | 6760.83 | nM | 5.17 |
| CHEMBL118321 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL324030 | — | IC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL55360 | — | IC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL56879 | — | IC50 | = | 10964.78 | nM | 4.96 |
| CHEMBL56542 | — | IC50 | = | 12022.64 | nM | 4.92 |
| CHEMBL56132 | — | IC50 | = | 14125.38 | nM | 4.85 |
| CHEMBL331026 | — | IC50 | = | 14454.4 | nM | 4.84 |
| CHEMBL54471 | — | IC50 | = | 15135.61 | nM | 4.82 |
| CHEMBL141175 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL141238 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL118109 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL55993 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL115895 | — | IC50 | = | 21877.62 | nM | 4.66 |
| CHEMBL334032 | — | IC50 | = | 22908.68 | nM | 4.64 |
| CHEMBL57251 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL55994 | — | IC50 | = | 30902.95 | nM | 4.51 |
| CHEMBL1161234 | — | IC50 | = | 47863.01 | nM | 4.32 |
| CHEMBL56319 | — | IC50 | = | 48977.88 | nM | 4.31 |
| CHEMBL1161236 | — | IC50 | = | 53703.18 | nM | 4.27 |
| CHEMBL116423 | — | IC50 | = | 61659.5 | nM | 4.21 |
| CHEMBL115519 | — | IC50 | = | 83176.38 | nM | 4.08 |
| CHEMBL120564 | — | IC50 | = | 87096.36 | nM | 4.06 |
| CHEMBL140213 | — | IC50 | = | 501187.23 | nM | - |