Assay Detail
Functional
CHEMBL676146
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGF-dependent DNA synthesis in ER 22 cells incubated with [3H]TdR
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | ER 22 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor-associated tyrosine kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.79 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334334 | — | — | 1 | 5.05 |
| CHEMBL131653 | — | — | 1 | 5.05 |
| CHEMBL129930 | — | — | 1 | 5.02 |
| CHEMBL133283 | — | — | 1 | 5.00 |
| CHEMBL132907 | — | — | 1 | 4.70 |
| CHEMBL423159 | — | — | 1 | 4.68 |
| CHEMBL319620 | LAVENDUSTIN C | — | 1 | 4.04 |
| CHEMBL316764 | — | — | 1 | - |
| CHEMBL129989 | — | — | 1 | - |
| CHEMBL130694 | — | — | 1 | - |
| CHEMBL130116 | — | — | 1 | - |
| CHEMBL130893 | — | — | 1 | - |
| CHEMBL129907 | — | — | 1 | - |
| CHEMBL130337 | — | — | 1 | - |
| CHEMBL131407 | — | — | 1 | - |
| CHEMBL335074 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334334 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL131653 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL129930 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL133283 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL132907 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL423159 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL319620 | LAVENDUSTIN C | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL316764 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL129989 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL130694 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL130116 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL130893 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129907 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL130337 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL131407 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL335074 | — | IC50 | > | 10000.0 | nM | - |