Assay Detail
Binding
CHEMBL676152
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In vitro inhibition of HER1 autophosphorylation.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.21 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56543 | — | — | 1 | 7.00 |
| CHEMBL53898 | — | — | 1 | 6.16 |
| CHEMBL56731 | — | — | 1 | 5.90 |
| CHEMBL56219 | — | — | 1 | 5.68 |
| CHEMBL55979 | — | — | 1 | 5.60 |
| CHEMBL296407 | — | — | 1 | 5.35 |
| CHEMBL440298 | — | — | 1 | 5.30 |
| CHEMBL56393 | — | — | 1 | 5.30 |
| CHEMBL417941 | — | — | 1 | 5.23 |
| CHEMBL59145 | — | — | 1 | 5.18 |
| CHEMBL55360 | — | — | 1 | 4.99 |
| CHEMBL56879 | — | — | 1 | 4.96 |
| CHEMBL56542 | — | — | 1 | 4.92 |
| CHEMBL56132 | — | — | 1 | 4.85 |
| CHEMBL54471 | — | — | 1 | 4.82 |
| CHEMBL55993 | — | — | 1 | 4.62 |
| CHEMBL55994 | — | — | 1 | 4.51 |
| CHEMBL56319 | — | — | 1 | 4.31 |
| CHEMBL291986 | — | — | 1 | 4.26 |
| CHEMBL293749 | — | — | 1 | - |
| CHEMBL57251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56543 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL53898 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL56731 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL56219 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL55979 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL296407 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL440298 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL56393 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL417941 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL59145 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL55360 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL56879 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL56542 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL56132 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL54471 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL55993 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL55994 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL56319 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL291986 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL293749 | — | IC50 | < | 625.0 | nM | - |
| CHEMBL57251 | — | IC50 | > | 166000.0 | nM | - |