Assay Detail
Binding
CHEMBL676158
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Epidermal growth factor receptor from human A431 carcinoma cell membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 11. Soluble analogues of pyrrolo- and pyrazoloquinazolines as epidermal growth factor receptor inhibitors: synthesis, biological evaluation, and modeling of the mode of binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.36 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39337 | — | — | 1 | 9.36 |
| CHEMBL40734 | — | — | 1 | 9.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39337 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL40734 | — | IC50 | = | 0.44 | nM | 9.36 |