Assay Detail
Functional
CHEMBL676236
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Tested in vitro for the beta lactamase inhibition of Escherichia coli TEM
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antibacterial activity of (1R, 5R, 6R)-2-tert-butyl-6-(1-hydroxyethyl)penem-3-carboxylic acid
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.74 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 7.40 |
| CHEMBL69141 | — | — | 1 | 7.30 |
| CHEMBL304733 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL69141 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL304733 | — | IC50 | = | 3000.0 | nM | 5.52 |