Assay Detail
Binding
CHEMBL676289
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Binding affinity against Dopamine receptor D3 expressed in CHO-K1 cells, using [3H]spiperone as the radioligand.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.22 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303021 | — | — | 1 | 7.82 |
| CHEMBL302171 | — | — | 1 | 7.66 |
| CHEMBL302172 | — | — | 1 | 7.52 |
| CHEMBL65196 | — | — | 1 | 7.43 |
| CHEMBL70589 | — | — | 1 | 7.37 |
| CHEMBL308347 | — | — | 1 | 7.35 |
| CHEMBL306869 | — | — | 1 | 7.26 |
| CHEMBL69562 | — | — | 1 | 7.17 |
| CHEMBL302994 | — | — | 1 | 6.97 |
| CHEMBL71395 | — | — | 1 | 6.50 |
| CHEMBL71804 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303021 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL302171 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL302172 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL65196 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL70589 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL308347 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL306869 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL69562 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL302994 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL71395 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL71804 | — | Ki | = | 391.0 | nM | 6.41 |