Compound Detail
CHEMBL69562
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Basic Information
| ChEMBL ID | CHEMBL69562 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BLMNALZUWKHXKM-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
284.4
MW (Da)
4.46
ALogP
1
HBA
1
HBD
19.0
PSA (Ų)
0.86
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 7.89 | 7.89 | 13.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | Ki | 7.85 | 7.85 | 14.0 | 1 |
| 5-hydroxytryptamine receptor 1D CHEMBL1983 | Ki | 7.37 | 7.37 | 43.0 | 1 |
| D(3) dopamine receptor CHEMBL3138 | Ki | 7.17 | 7.17 | 67.0 | 1 |
| 5-hydroxytryptamine receptor 1B CHEMBL1898 | Ki | 6.1 | 6.1 | 789.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Ki | = | 13.0 | nM | 7.89 | Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, usin... | 7783152 |
| D(2) dopamine receptor | Ki | = | 14.0 | nM | 7.85 | Binding affinity against Dopamine receptor D2 expressed in CHO-K1 cells, using [... | 7783152 |
| 5-hydroxytryptamine receptor 1D | Ki | = | 43.0 | nM | 7.37 | Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-... | 7783152 |
| D(3) dopamine receptor | Ki | = | 67.0 | nM | 7.17 | Binding affinity against Dopamine receptor D3 expressed in CHO-K1 cells, using [... | 7783152 |
| 5-hydroxytryptamine receptor 1B | Ki | = | 789.0 | nM | 6.1 | Binding affinity against 5-hydroxytryptamine 1D receptor beta expressed in CHO-K... | 7783152 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7783152 | 10.1021/jm00012a021 | 5-hydroxytryptamine receptor 1A | 1 |
| 7783152 | 10.1021/jm00012a021 | 5-hydroxytryptamine receptor 1D | 1 |
| 7783152 | 10.1021/jm00012a021 | 5-hydroxytryptamine receptor 1B | 1 |
| 7783152 | 10.1021/jm00012a021 | D(2) dopamine receptor | 1 |
| 7783152 | 10.1021/jm00012a021 | D(3) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine