Assay Detail
Binding
CHEMBL617092
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Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand.
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.27 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71176 | — | — | 1 | 8.36 |
| CHEMBL441256 | — | — | 1 | 8.34 |
| CHEMBL308347 | — | — | 1 | 8.17 |
| CHEMBL70589 | — | — | 1 | 8.12 |
| CHEMBL71663 | — | — | 1 | 8.08 |
| CHEMBL71474 | — | — | 1 | 8.07 |
| CHEMBL305743 | — | — | 1 | 7.96 |
| CHEMBL70710 | — | — | 1 | 7.85 |
| CHEMBL302172 | — | — | 1 | 7.80 |
| CHEMBL306869 | — | — | 1 | 7.75 |
| CHEMBL303021 | — | — | 1 | 7.64 |
| CHEMBL71091 | — | — | 1 | 7.58 |
| CHEMBL71625 | — | — | 1 | 7.51 |
| CHEMBL70652 | — | — | 1 | 7.47 |
| CHEMBL70985 | — | — | 1 | 7.44 |
| CHEMBL65196 | — | — | 1 | 7.40 |
| CHEMBL71804 | — | — | 1 | 7.38 |
| CHEMBL69562 | — | — | 1 | 7.37 |
| CHEMBL303269 | — | — | 1 | 7.28 |
| CHEMBL71247 | — | — | 1 | 7.27 |
| CHEMBL71899 | — | — | 1 | 7.27 |
| CHEMBL70431 | — | — | 1 | 7.06 |
| CHEMBL71395 | — | — | 1 | 6.97 |
| CHEMBL302263 | — | — | 1 | 6.95 |
| CHEMBL307786 | — | — | 1 | 6.81 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.79 |
| CHEMBL304426 | — | — | 1 | 6.76 |
| CHEMBL70882 | — | — | 1 | 6.66 |
| CHEMBL304573 | — | — | 1 | 6.53 |
| CHEMBL71299 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71176 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL441256 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL308347 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL70589 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL71663 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL71474 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL305743 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL70710 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL302172 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL306869 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL303021 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL71091 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL71625 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL70652 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL70985 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL65196 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL71804 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL69562 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL303269 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL71899 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL71247 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL70431 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL71395 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL302263 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL307786 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL304426 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL70882 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL304573 | — | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL71299 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL71319 | — | Ki | = | 419.0 | nM | 6.38 |
| CHEMBL307521 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL302171 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL302373 | — | Ki | = | 585.0 | nM | 6.23 |
| CHEMBL71676 | — | Ki | = | 762.0 | nM | 6.12 |
| CHEMBL71454 | — | Ki | - | nM | - |