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Compound Detail

CHEMBL71176

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CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1

Basic Information

ChEMBL ID CHEMBL71176
Phase Preclinical
Structure Type MOL
InChI Key ICOOOYKBBQSJND-OAHLLOKOSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

316.4
MW (Da)
4.10
ALogP
2
HBA
1
HBD
36.1
PSA (Ų)
0.81
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H25FN2O
MW 316.42
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.38

Activity Summary

Ki 4 meas. best 9.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 1A
CHEMBL273
Ki 9.52 9.52 0.3 1
5-hydroxytryptamine receptor 1D
CHEMBL1983
Ki 8.36 8.36 4.4 1
D(2) dopamine receptor
CHEMBL339
Ki 7.32 7.32 48.0 1
D(3) dopamine receptor
CHEMBL3138
Ki 7.26 7.26 55.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
7783152 10.1021/jm00012a021 Rattus norvegicus 6
7783152 10.1021/jm00012a021 5-hydroxytryptamine receptor 1A 1
7783152 10.1021/jm00012a021 5-hydroxytryptamine receptor 1D 1
7783152 10.1021/jm00012a021 D(2) dopamine receptor 1
7783152 10.1021/jm00012a021 D(3) dopamine receptor 1

Data from ChEMBL 36 via Core Engine