Assay Detail
Binding
CHEMBL676292
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Binding affinity against Dopamine receptor D3 from CHO-K1 cells, using [3H]spiperone as the radioligand.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.12 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305743 | — | — | 1 | 8.80 |
| CHEMBL304573 | — | — | 1 | 8.39 |
| CHEMBL70710 | — | — | 1 | 7.85 |
| CHEMBL71091 | — | — | 1 | 7.64 |
| CHEMBL71625 | — | — | 1 | 7.29 |
| CHEMBL70882 | — | — | 1 | 7.28 |
| CHEMBL71176 | — | — | 1 | 7.26 |
| CHEMBL71474 | — | — | 1 | 7.20 |
| CHEMBL304426 | — | — | 1 | 7.16 |
| CHEMBL70652 | — | — | 1 | 7.11 |
| CHEMBL71676 | — | — | 1 | 7.11 |
| CHEMBL71663 | — | — | 1 | 6.96 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.48 |
| CHEMBL70985 | — | — | 1 | 6.27 |
| CHEMBL302263 | — | — | 1 | 6.17 |
| CHEMBL307786 | — | — | 1 | 6.12 |
| CHEMBL71299 | — | — | 1 | 6.00 |
| CHEMBL71247 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305743 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL304573 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL70710 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL71091 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL71625 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL70882 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL71176 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL71474 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL304426 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL70652 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL71676 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL71663 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 333.0 | nM | 6.48 |
| CHEMBL70985 | — | Ki | = | 542.0 | nM | 6.27 |
| CHEMBL302263 | — | Ki | = | 675.0 | nM | 6.17 |
| CHEMBL307786 | — | Ki | = | 751.0 | nM | 6.12 |
| CHEMBL71299 | — | Ki | = | 1012.0 | nM | 6.00 |
| CHEMBL71247 | — | Ki | - | nM | - |