Assay Detail
Binding
CHEMBL616594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]8-OH-DPAT as the radioligand.
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 8.30 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307786 | — | — | 1 | 9.70 |
| CHEMBL304426 | — | — | 1 | 9.70 |
| CHEMBL71625 | — | — | 1 | 9.70 |
| CHEMBL71176 | — | — | 1 | 9.52 |
| CHEMBL70589 | — | — | 1 | 9.40 |
| CHEMBL71804 | — | — | 1 | 9.30 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 9.30 |
| CHEMBL441256 | — | — | 1 | 9.30 |
| CHEMBL70652 | — | — | 1 | 9.10 |
| CHEMBL308347 | — | — | 1 | 9.10 |
| CHEMBL302171 | — | — | 1 | 8.85 |
| CHEMBL305743 | — | — | 1 | 8.85 |
| CHEMBL70710 | — | — | 1 | 8.82 |
| CHEMBL303021 | — | — | 1 | 8.70 |
| CHEMBL71474 | — | — | 1 | 8.64 |
| CHEMBL65196 | — | — | 1 | 8.48 |
| CHEMBL304573 | — | — | 1 | 8.43 |
| CHEMBL302172 | — | — | 1 | 8.28 |
| CHEMBL70985 | — | — | 1 | 8.15 |
| CHEMBL71139 | — | — | 1 | 8.14 |
| CHEMBL302994 | — | — | 1 | 8.07 |
| CHEMBL71663 | — | — | 1 | 7.96 |
| CHEMBL303269 | — | — | 1 | 7.96 |
| CHEMBL306869 | — | — | 1 | 7.89 |
| CHEMBL69562 | — | — | 1 | 7.89 |
| CHEMBL71395 | — | — | 1 | 7.85 |
| CHEMBL71091 | — | — | 1 | 7.85 |
| CHEMBL71247 | — | — | 1 | 7.77 |
| CHEMBL71899 | — | — | 1 | 7.75 |
| CHEMBL302263 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307786 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL71625 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL304426 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL71176 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL70589 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL71804 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL441256 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL70652 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL308347 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL305743 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL302171 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL70710 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL303021 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL71474 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL65196 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL304573 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL302172 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL70985 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL71139 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL302994 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL71663 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL303269 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL306869 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL69562 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL71395 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL71091 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL71247 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL71899 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL302263 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL70431 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL71319 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL71299 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL307521 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL71454 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL71676 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL302373 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL70882 | — | Ki | = | 250.0 | nM | 6.60 |