Assay Detail
Binding
CHEMBL676299
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Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.27 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110239 | — | — | 1 | 9.00 |
| CHEMBL285755 | — | — | 1 | 8.93 |
| CHEMBL6066838 | — | — | 1 | 8.41 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.25 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.03 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.84 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.31 |
| CHEMBL25554 | — | — | 1 | 6.97 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.61 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.12 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 5.82 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 5.63 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 5.61 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | - |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110239 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL285755 | — | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL6066838 | — | Ki | = | 3.91 | nM | 8.41 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 5.65 | nM | 8.25 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 9.25 | nM | 8.03 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL59 | DOPAMINE | Ki | = | 49.3 | nM | 7.31 |
| CHEMBL25554 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL62 | SCH-23390 | Ki | = | 768.0 | nM | 6.12 |
| CHEMBL6437 | MIANSERIN | Ki | = | 1524.0 | nM | 5.82 |
| CHEMBL39 | SEROTONIN | Ki | = | 2338.0 | nM | 5.63 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 2430.0 | nM | 5.61 |
| CHEMBL80 | NALOXONE | Ki | > | 20000.0 | nM | - |
| CHEMBL27 | PROPRANOLOL | Ki | > | 5000.0 | nM | - |