Assay Detail
Binding
CHEMBL676380
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Binding affinity towards human recombinant Estrogen receptor beta was determined
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.10 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.96 |
| CHEMBL418327 | — | — | 1 | 8.29 |
| CHEMBL30439 | — | — | 1 | 8.05 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 7.92 |
| CHEMBL71584 | — | — | 1 | 7.35 |
| CHEMBL304552 | — | — | 1 | 7.35 |
| CHEMBL68940 | — | — | 1 | 7.16 |
| CHEMBL2111532 | — | — | 1 | 6.84 |
| CHEMBL539927 | — | — | 3 | 6.84 |
| CHEMBL71585 | — | — | 1 | 6.74 |
| CHEMBL286115 | — | — | 1 | 5.56 |
| CHEMBL70117 | — | — | 1 | 5.22 |
| CHEMBL68549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL418327 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL30439 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL71584 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL304552 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL68940 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2111532 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL539927 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL71585 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL539927 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL539927 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL286115 | — | IC50 | = | 2732.0 | nM | 5.56 |
| CHEMBL70117 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL68549 | — | IC50 | > | 100000.0 | nM | - |