Assay Detail
Functional
CHEMBL676554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETB receptors)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72037 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72037 | — | Kd | = | 1000.0 | nM | 6.00 |