Assay Detail
Functional
CHEMBL676576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of ET-1 induced contraction of rabbit femoral artery rings (Endothelin A receptor mediated)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Artery |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 7.60 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8981 | PD-156707 | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8981 | PD-156707 | Kd | = | 25.12 | nM | 7.60 |