Assay Detail
Functional
CHEMBL676676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro growth inhibition against Entamoeba histolytica
102
Total Activities
102
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 102 | 4.57 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 5.50 |
| CHEMBL434978 | — | — | 1 | 5.40 |
| CHEMBL53982 | — | — | 1 | 5.19 |
| CHEMBL55371 | — | — | 1 | 5.18 |
| CHEMBL293479 | — | — | 1 | 5.06 |
| CHEMBL298852 | — | — | 1 | 4.96 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 4.92 |
| CHEMBL54747 | — | — | 1 | 4.91 |
| CHEMBL54004 | — | — | 1 | 4.88 |
| CHEMBL431735 | — | — | 1 | 4.81 |
| CHEMBL412889 | (CYCLOOCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.81 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.80 |
| CHEMBL300755 | — | — | 1 | 4.72 |
| CHEMBL55464 | — | — | 1 | 4.69 |
| CHEMBL56078 | — | — | 1 | 4.66 |
| CHEMBL298547 | — | — | 1 | 4.65 |
| CHEMBL56073 | — | — | 1 | 4.63 |
| CHEMBL55027 | — | — | 1 | 4.54 |
| CHEMBL55264 | — | — | 1 | 4.53 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.51 |
| CHEMBL58830 | (CYCLOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.45 |
| CHEMBL433833 | — | — | 1 | 4.44 |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.43 |
| CHEMBL430963 | — | — | 1 | 4.40 |
| CHEMBL55837 | — | — | 1 | 4.36 |
| CHEMBL300532 | — | — | 1 | 4.36 |
| CHEMBL54537 | — | — | 1 | 4.35 |
| CHEMBL55353 | (BUTYL(ETHYL)AMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.33 |
| CHEMBL55988 | — | — | 1 | 4.27 |
| CHEMBL301065 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL434978 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL53982 | — | IC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL55371 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL293479 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL298852 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL54747 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL54004 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL412889 | (CYCLOOCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL431735 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL300755 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL55464 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL56078 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL298547 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL56073 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL55027 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL55264 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL58830 | (CYCLOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL433833 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL430963 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL300532 | — | IC50 | = | 44200.0 | nM | 4.36 |
| CHEMBL55837 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL54537 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL55353 | (BUTYL(ETHYL)AMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 47300.0 | nM | 4.33 |
| CHEMBL55988 | — | IC50 | = | 53600.0 | nM | 4.27 |
| CHEMBL301065 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 62600.0 | nM | 4.20 |
| CHEMBL416301 | — | IC50 | = | 63700.0 | nM | 4.20 |
| CHEMBL55959 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL54480 | — | IC50 | = | 65300.0 | nM | 4.18 |
| CHEMBL56047 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL55810 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 73500.0 | nM | 4.13 |
| CHEMBL54714 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL301854 | — | IC50 | = | 96100.0 | nM | 4.02 |
| CHEMBL55557 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL55886 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL293116 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL55358 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL54888 | — | IC50 | = | 132000.0 | nM | - |
| CHEMBL299988 | — | IC50 | = | 157000.0 | nM | - |
| CHEMBL52137 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL56028 | — | IC50 | = | 172000.0 | nM | - |
| CHEMBL294478 | (ISOBUTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL56704 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL870 | ALENDRONIC ACID | IC50 | > | 200000.0 | nM | - |