Assay Detail
Binding
CHEMBL676682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dopamine uptake via rat dopamine receptor.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.26 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34697 | — | — | 1 | 8.57 |
| CHEMBL36419 | — | — | 1 | 8.42 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.37 |
| CHEMBL36074 | — | — | 1 | 8.29 |
| CHEMBL33903 | — | — | 1 | 8.28 |
| CHEMBL290799 | — | — | 1 | 8.16 |
| CHEMBL416409 | — | — | 1 | 8.14 |
| CHEMBL284096 | — | — | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34697 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL36419 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL281594 | VANOXERINE | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL36074 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL33903 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL290799 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL416409 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL284096 | — | Ki | = | 13.6 | nM | 7.87 |