Assay Detail
Binding
CHEMBL676688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reuptake inhibitory activity against dopamine DA transporter
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.77 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | 2.0 | 1 | 8.70 |
| CHEMBL89142 | — | — | 1 | 8.52 |
| CHEMBL543372 | — | — | 1 | 7.92 |
| CHEMBL89752 | — | — | 1 | 7.50 |
| CHEMBL554565 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL89142 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL543372 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL89752 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL554565 | — | Ki | = | 600.0 | nM | 6.22 |