Assay Detail
Functional
CHEMBL676808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alpha
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and estrogenic activities of novel 7-thiosubstituted estratriene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.68 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627355 | — | — | 1 | 8.30 |
| CHEMBL1627353 | — | — | 1 | 8.15 |
| CHEMBL1628170 | — | — | 1 | 7.89 |
| CHEMBL1628199 | — | — | 1 | 7.55 |
| CHEMBL1627351 | — | — | 1 | 7.40 |
| CHEMBL1627356 | — | — | 1 | 6.76 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627355 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1627353 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1628170 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1628199 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1627351 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1627356 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.007 | nM | - |