Assay Detail
Binding
CHEMBL676818
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human estrogen receptor alpha in competitive binding assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.89 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.89 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 8.74 |
| CHEMBL30439 | — | — | 1 | 8.17 |
| CHEMBL30707 | COUMESTROL | — | 1 | 7.96 |
| CHEMBL30950 | — | — | 1 | 7.85 |
| CHEMBL286115 | — | — | 1 | 7.51 |
| CHEMBL284453 | — | — | 1 | 7.31 |
| CHEMBL34679 | — | — | 1 | 7.24 |
| CHEMBL33808 | — | — | 1 | 7.17 |
| CHEMBL33890 | — | — | 1 | 7.15 |
| CHEMBL282292 | — | — | 1 | 7.05 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 7.04 |
| CHEMBL33568 | — | — | 1 | 6.98 |
| CHEMBL31128 | — | — | 1 | 6.96 |
| CHEMBL33053 | — | — | 1 | 6.83 |
| CHEMBL285632 | — | — | 1 | 6.75 |
| CHEMBL33230 | — | — | 1 | 6.38 |
| CHEMBL31127 | — | — | 1 | 6.31 |
| CHEMBL30574 | — | — | 1 | 6.28 |
| CHEMBL30769 | — | — | 1 | 6.26 |
| CHEMBL291002 | — | — | 1 | 6.19 |
| CHEMBL33888 | — | — | 1 | 6.03 |
| CHEMBL33625 | — | — | 1 | 5.98 |
| CHEMBL33263 | — | — | 1 | 5.98 |
| CHEMBL417126 | — | — | 1 | 5.85 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | 5.67 |
| CHEMBL280538 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL30439 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL30707 | COUMESTROL | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL30950 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL286115 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL284453 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL34679 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL33808 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL33890 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL282292 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL44 | GENISTEIN | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL33568 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL31128 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL33053 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL285632 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL33230 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL31127 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL30574 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL30769 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL291002 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL33888 | — | IC50 | = | 929.0 | nM | 6.03 |
| CHEMBL33625 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL33263 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL417126 | — | IC50 | = | 1415.0 | nM | 5.85 |
| CHEMBL8145 | DAIDZEIN | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL280538 | — | IC50 | = | 3563.0 | nM | 5.45 |