Assay Detail
Binding
CHEMBL676819
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Binding affinity towards estrogen receptor alpha by [3H]17-beta-estradiol displacement.
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of 3-arylbenzoxazines as selective estrogen receptor beta agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.70 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 7.96 |
| CHEMBL77609 | — | — | 1 | 6.75 |
| CHEMBL1405 | ESTRONE | 4.0 | 1 | 6.68 |
| CHEMBL77620 | — | — | 1 | 6.50 |
| CHEMBL74758 | — | — | 1 | 6.07 |
| CHEMBL77930 | — | — | 1 | 5.92 |
| CHEMBL306636 | — | — | 1 | 5.77 |
| CHEMBL74757 | — | — | 1 | 5.77 |
| CHEMBL264862 | — | — | 3 | 5.55 |
| CHEMBL77466 | — | — | 1 | 5.28 |
| CHEMBL73989 | — | — | 1 | 5.25 |
| CHEMBL74027 | — | — | 1 | 5.22 |
| CHEMBL77851 | — | — | 1 | 5.22 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 5.21 |
| CHEMBL307205 | — | — | 1 | 5.07 |
| CHEMBL77794 | — | — | 1 | 4.80 |
| CHEMBL74022 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL77609 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1405 | ESTRONE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL77620 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL74758 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL77930 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL74757 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL306636 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL264862 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL264862 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL77466 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL73989 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL74027 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL77851 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL44 | GENISTEIN | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL264862 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL307205 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL77794 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL74022 | — | IC50 | = | 33000.0 | nM | 4.48 |