Assay Detail
Binding
CHEMBL676881
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Fibroblast growth factor receptor (FGFr) tyrosine kinase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Fibroblast growth factor receptor (CHEMBL2095217) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.95 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301483 | — | — | 1 | 7.48 |
| CHEMBL45827 | — | — | 1 | 7.32 |
| CHEMBL57347 | — | — | 1 | 7.29 |
| CHEMBL299763 | — | — | 1 | 7.22 |
| CHEMBL299026 | — | — | 1 | 7.09 |
| CHEMBL57366 | — | — | 1 | 6.89 |
| CHEMBL432738 | — | — | 1 | 6.89 |
| CHEMBL75188 | — | — | 1 | 6.85 |
| CHEMBL57323 | — | — | 1 | 6.40 |
| CHEMBL56236 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301483 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL45827 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL57347 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL299763 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL299026 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL57366 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL432738 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL75188 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL57323 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL56236 | — | IC50 | = | 780.0 | nM | 6.11 |