Compound Detail
CHEMBL56236
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Basic Information
| ChEMBL ID | CHEMBL56236 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NNYHIJGVHOAIGK-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
16
Publications
0
Known Names
Molecular Properties
392.5
MW (Da)
4.43
ALogP
5
HBA
3
HBD
105.8
PSA (Ų)
0.60
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.15 | 6.15 | 710.0 | 2 |
| Fibroblast growth factor receptor CHEMBL2095217 | IC50 | 6.11 | 6.11 | 780.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 5.17 | 5.17 | 6680.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 710.0 | nM | 6.15 | Ability to prevent phosphorylation of human fibroblast growth factor receptor 1 | 11384237 |
| Fibroblast growth factor receptor 1 | IC50 | = | 710.0 | nM | 6.15 | Inhibition of the fibroblast growth factor receptor (FGFR1) | - |
| Fibroblast growth factor receptor | IC50 | = | 780.0 | nM | 6.11 | Inhibition of Fibroblast growth factor receptor (FGFr) tyrosine kinase | 9240345 |
| Epidermal growth factor receptor | IC50 | = | 6680.0 | nM | 5.17 | Inhibition of Epidermal growth factor receptor (EGFr) tyrosine kinase | 9240345 |
| Epidermal growth factor receptor | IC50 | = | 6680.0 | nM | 5.17 | Inhibition of EGF-receptor | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9240345 | 10.1021/jm970367n | Platelet-derived growth factor receptor (PDGFr) | 2 |
| 9240345 | 10.1021/jm970367n | Fibroblast growth factor receptor | 1 |
| 9240345 | 10.1021/jm970367n | Epidermal growth factor receptor | 1 |
| 9240345 | 10.1021/jm970367n | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 9240345 | 10.1021/jm970367n | Insulin receptor | 1 |
| 11384237 | 10.1021/jm0004291 | Platelet-derived growth factor receptor beta | 1 |
| 11384237 | 10.1021/jm0004291 | Fibroblast growth factor receptor 1 | 1 |
| 11384237 | 10.1021/jm0004291 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Mitogen-activated protein kinase; ERK1/ERK2 | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Cyclin-dependent kinase 4 | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Epidermal growth factor receptor | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Insulin receptor | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Protein kinase C (PKC) | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Platelet-derived growth factor receptor | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine