Assay Detail
Binding
CHEMBL675521
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Epidermal growth factor receptor (EGFr) tyrosine kinase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.92 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57347 | — | — | 1 | 6.82 |
| CHEMBL45827 | — | — | 1 | 6.62 |
| CHEMBL57366 | — | — | 1 | 6.35 |
| CHEMBL57323 | — | — | 1 | 6.21 |
| CHEMBL301483 | — | — | 1 | 5.90 |
| CHEMBL432738 | — | — | 1 | 5.87 |
| CHEMBL299026 | — | — | 1 | 5.21 |
| CHEMBL56236 | — | — | 1 | 5.17 |
| CHEMBL75188 | — | — | 1 | 5.16 |
| CHEMBL299763 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57347 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL45827 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL57366 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL57323 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL301483 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL432738 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL299026 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL56236 | — | IC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL75188 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL299763 | — | IC50 | > | 50000.0 | nM | - |