Assay Detail
Binding
CHEMBL676884
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the fibroblast growth factor receptor (FGFR1)
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery and structure-activity studies of a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.02 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299763 | — | — | 1 | 7.22 |
| CHEMBL77781 | — | — | 1 | 6.96 |
| CHEMBL312048 | — | — | 1 | 6.96 |
| CHEMBL57366 | — | — | 1 | 6.85 |
| CHEMBL79274 | — | — | 1 | 6.80 |
| CHEMBL312454 | — | — | 1 | 6.75 |
| CHEMBL81615 | — | — | 1 | 6.57 |
| CHEMBL300171 | — | — | 1 | 6.54 |
| CHEMBL82431 | — | — | 1 | 6.47 |
| CHEMBL81146 | — | — | 1 | 6.44 |
| CHEMBL57323 | — | — | 1 | 6.40 |
| CHEMBL78485 | — | — | 1 | 6.17 |
| CHEMBL56236 | — | — | 1 | 6.15 |
| CHEMBL312148 | — | — | 1 | 6.05 |
| CHEMBL81975 | — | — | 1 | 5.96 |
| CHEMBL81474 | — | — | 1 | 5.95 |
| CHEMBL78393 | — | — | 1 | 5.85 |
| CHEMBL78555 | — | — | 1 | 5.79 |
| CHEMBL309470 | — | — | 1 | 5.78 |
| CHEMBL48809 | — | — | 1 | 5.78 |
| CHEMBL312055 | — | — | 1 | 5.40 |
| CHEMBL445893 | — | — | 1 | 5.11 |
| CHEMBL76599 | — | — | 1 | 5.10 |
| CHEMBL421145 | — | — | 1 | 4.95 |
| CHEMBL79241 | — | — | 1 | 4.95 |
| CHEMBL50371 | — | — | 1 | 4.80 |
| CHEMBL78802 | — | — | 1 | 4.69 |
| CHEMBL49658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299763 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL77781 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL312048 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL57366 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL79274 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL312454 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL81615 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL300171 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL82431 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL81146 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL57323 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL78485 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL56236 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL312148 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL81975 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL81474 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL78393 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL78555 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL309470 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL48809 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL312055 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL445893 | — | IC50 | = | 7760.0 | nM | 5.11 |
| CHEMBL76599 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL421145 | — | IC50 | = | 11220.0 | nM | 4.95 |
| CHEMBL79241 | — | IC50 | = | 11220.0 | nM | 4.95 |
| CHEMBL50371 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL78802 | — | IC50 | = | 20250.0 | nM | 4.69 |
| CHEMBL49658 | — | IC50 | > | 50000.0 | nM | - |