Compound Detail
CHEMBL50371
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL50371 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VUMSJQHDUMFUHU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
422.5
MW (Da)
3.33
ALogP
7
HBA
3
HBD
112.3
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 4.8 | 4.8 | 16000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 16000.0 | nM | 4.8 | Inhibition of the fibroblast growth factor receptor (FGFR1) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17964795 | 10.1016/j.bmc.2007.10.024 | Unchecked | 2 |
| - | 10.1016/S0960-894X(97)00445-9 | Platelet-derived growth factor receptor | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Fibroblast growth factor receptor 1 | 1 |
| - | 10.1016/S0960-894X(97)00445-9 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 9599227 | 10.1021/jm970634p | Platelet-derived growth factor receptor | 1 |
| 9599227 | 10.1021/jm970634p | Fibroblast growth factor receptor | 1 |
| 9599227 | 10.1021/jm970634p | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 9599227 | 10.1021/jm970634p | Epidermal growth factor receptor | 1 |
| 17964795 | 10.1016/j.bmc.2007.10.024 | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine