Assay Detail
Binding
CHEMBL676969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound against human fibroblast growth factor receptor
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Fibroblast growth factor receptor (CHEMBL2095217) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.77 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51028 | — | — | 1 | 7.40 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 7.36 |
| CHEMBL297523 | — | — | 1 | 7.32 |
| CHEMBL45827 | — | — | 1 | 7.32 |
| CHEMBL51283 | — | — | 1 | 7.29 |
| CHEMBL432314 | — | — | 1 | 7.29 |
| CHEMBL299763 | — | — | 1 | 7.22 |
| CHEMBL50647 | — | — | 1 | 7.21 |
| CHEMBL296540 | — | — | 1 | 6.90 |
| CHEMBL51485 | — | — | 1 | 6.90 |
| CHEMBL298679 | — | — | 1 | 6.86 |
| CHEMBL299194 | — | — | 1 | 6.46 |
| CHEMBL301612 | — | — | 1 | 6.29 |
| CHEMBL48172 | — | — | 1 | 5.90 |
| CHEMBL49596 | — | — | 1 | 5.88 |
| CHEMBL48809 | — | — | 1 | 5.78 |
| CHEMBL50470 | — | — | 1 | 5.71 |
| CHEMBL49658 | — | — | 1 | - |
| CHEMBL51573 | — | — | 1 | - |
| CHEMBL50977 | — | — | 1 | - |
| CHEMBL299347 | — | — | 1 | - |
| CHEMBL50371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51028 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL297523 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL45827 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL51283 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL432314 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL299763 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL50647 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL296540 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL51485 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL298679 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL299194 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL301612 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL48172 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL49596 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL48809 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL50470 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL49658 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL51573 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL50977 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL299347 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL50371 | — | IC50 | > | 16000.0 | nM | - |