Assay Detail
Binding
CHEMBL676971
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Inhibition fibroblast growth factor receptor TK kinase activity at a concentration of 2 uM
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.40 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2448066 | — | — | 1 | 6.05 |
| CHEMBL1202473 | — | — | 1 | 5.82 |
| CHEMBL416191 | — | — | 1 | 5.82 |
| CHEMBL25579 | — | — | 1 | 5.80 |
| CHEMBL422758 | — | — | 1 | 5.77 |
| CHEMBL1907764 | — | — | 1 | 5.75 |
| CHEMBL1907763 | — | — | 1 | 5.75 |
| CHEMBL279459 | — | — | 1 | 5.72 |
| CHEMBL1744349 | — | — | 1 | 5.72 |
| CHEMBL1202477 | — | — | 1 | 5.70 |
| CHEMBL1202478 | — | — | 1 | 5.68 |
| CHEMBL1744347 | — | — | 1 | 5.68 |
| CHEMBL24979 | — | — | 1 | 5.68 |
| CHEMBL25450 | — | — | 1 | 5.60 |
| CHEMBL26641 | — | — | 1 | 5.57 |
| CHEMBL533849 | — | — | 1 | 5.44 |
| CHEMBL25425 | — | — | 1 | 5.39 |
| CHEMBL2448067 | — | — | 1 | 5.38 |
| CHEMBL2448065 | — | — | 1 | 5.37 |
| CHEMBL2448064 | — | — | 1 | 5.30 |
| CHEMBL1907944 | — | — | 1 | 5.30 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 5.22 |
| CHEMBL24137 | — | — | 1 | 5.17 |
| CHEMBL283088 | — | — | 1 | 5.10 |
| CHEMBL428534 | — | — | 1 | 4.91 |
| CHEMBL281990 | — | — | 1 | 4.87 |
| CHEMBL25610 | — | — | 1 | 4.72 |
| CHEMBL24026 | — | — | 1 | 4.72 |
| CHEMBL286160 | — | — | 1 | 4.57 |
| CHEMBL26050 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2448066 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1202473 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL416191 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL25579 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL422758 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1907764 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1907763 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL279459 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1744349 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1202477 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1202478 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1744347 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL24979 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL25450 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL26641 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL533849 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL25425 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2448067 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2448065 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2448064 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1907944 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL24137 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL283088 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL428534 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL281990 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL25610 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL24026 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL286160 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL26050 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL281872 | ZD-4190 FREE BASE | IC50 | > | 100000.0 | nM | - |