Assay Detail
Binding
CHEMBL677050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro concentration required to inhibit [3H]estradiol binding to human estrogen receptor beta expressed in 293T cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | 293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.35 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92748 | — | — | 1 | 8.92 |
| CHEMBL93586 | — | — | 1 | 8.32 |
| CHEMBL93391 | — | — | 1 | 8.06 |
| CHEMBL93326 | — | — | 1 | 8.05 |
| CHEMBL93792 | — | — | 1 | 7.97 |
| CHEMBL93266 | — | — | 1 | 7.94 |
| CHEMBL93826 | — | — | 1 | 7.88 |
| CHEMBL420244 | — | — | 1 | 7.73 |
| CHEMBL93230 | — | — | 1 | 7.67 |
| CHEMBL313849 | — | — | 1 | 7.66 |
| CHEMBL316080 | — | — | 1 | 7.65 |
| CHEMBL328675 | — | — | 1 | 7.58 |
| CHEMBL329630 | — | — | 1 | 7.56 |
| CHEMBL93207 | — | — | 1 | 7.55 |
| CHEMBL94280 | — | — | 1 | 7.38 |
| CHEMBL421368 | — | — | 1 | 7.38 |
| CHEMBL91052 | — | — | 1 | 7.31 |
| CHEMBL91452 | — | — | 1 | 7.20 |
| CHEMBL315866 | — | — | 1 | 7.18 |
| CHEMBL330307 | — | — | 1 | 7.15 |
| CHEMBL89994 | — | — | 1 | 7.03 |
| CHEMBL412907 | — | — | 1 | 7.00 |
| CHEMBL91740 | — | — | 1 | 6.88 |
| CHEMBL90008 | — | — | 1 | 6.75 |
| CHEMBL92900 | — | — | 1 | 6.66 |
| CHEMBL89995 | — | — | 1 | 6.53 |
| CHEMBL94080 | — | — | 1 | 6.53 |
| CHEMBL328475 | — | — | 1 | 5.97 |
| CHEMBL316292 | — | — | 1 | 5.65 |
| CHEMBL330029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92748 | — | IC50 | = | 1.21 | nM | 8.92 |
| CHEMBL93586 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL93391 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL93326 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL93792 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL93266 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL93826 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL420244 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL93230 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL313849 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL316080 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL328675 | — | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL329630 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL93207 | — | IC50 | = | 27.9 | nM | 7.55 |
| CHEMBL94280 | — | IC50 | = | 42.2 | nM | 7.38 |
| CHEMBL421368 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL91052 | — | IC50 | = | 48.8 | nM | 7.31 |
| CHEMBL91452 | — | IC50 | = | 63.5 | nM | 7.20 |
| CHEMBL315866 | — | IC50 | = | 66.4 | nM | 7.18 |
| CHEMBL330307 | — | IC50 | = | 71.2 | nM | 7.15 |
| CHEMBL89994 | — | IC50 | = | 93.3 | nM | 7.03 |
| CHEMBL412907 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL91740 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL90008 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL92900 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL89995 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL94080 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL328475 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL316292 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL330029 | — | IC50 | > | 3200.0 | nM | - |