Assay Detail
Binding
CHEMBL677128
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In vitro inhibition of mouse liver Folyl-polyglutamate synthase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Folylpolyglutamate synthase, mitochondrial (CHEMBL2890) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.59 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289923 | — | — | 1 | 7.52 |
| CHEMBL38902 | — | — | 1 | 5.50 |
| CHEMBL35921 | — | — | 1 | 5.24 |
| CHEMBL40850 | — | — | 1 | 5.05 |
| CHEMBL417696 | — | — | 1 | 4.66 |
| CHEMBL39175 | — | — | 1 | - |
| CHEMBL294973 | — | — | 1 | - |
| CHEMBL41459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289923 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL38902 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL35921 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL40850 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL417696 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL39175 | — | Ki | = | 570000.0 | nM | - |
| CHEMBL294973 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL41459 | — | Ki | = | 115000.0 | nM | - |