Assay Detail
Binding
CHEMBL677169
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50% inhibition of human recombinant fibroblast collagenase (MMP-1, HFC)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibition of Matrix Metalloproteinases: An examination of the S1 pocket
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.03 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 8.30 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.30 |
| CHEMBL58945 | — | — | 1 | 7.70 |
| CHEMBL60546 | — | — | 1 | 7.70 |
| CHEMBL294066 | — | — | 1 | 6.82 |
| CHEMBL62245 | — | — | 1 | 6.40 |
| CHEMBL62056 | — | — | 1 | 6.30 |
| CHEMBL293382 | — | — | 1 | 6.00 |
| CHEMBL58997 | — | — | 1 | 5.30 |
| CHEMBL416510 | — | — | 1 | 5.16 |
| CHEMBL59185 | — | — | 1 | 5.16 |
| CHEMBL292160 | — | — | 1 | 5.10 |
| CHEMBL62186 | — | — | 1 | 4.70 |
| CHEMBL418472 | — | — | 1 | 4.70 |
| CHEMBL61538 | — | — | 1 | 4.52 |
| CHEMBL59722 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279786 | BATIMASTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL58945 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL60546 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL294066 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL62245 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL62056 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL293382 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL58997 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL416510 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL59185 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL292160 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL62186 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL418472 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL61538 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL59722 | — | IC50 | = | 50000.0 | nM | 4.30 |