Assay Detail
Binding
CHEMBL677170
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Inhibition of human recombinant fibroblast collagenase (MMP-1, HFC)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibition of Matrix Metalloproteinases: An examination of the S1 pocket
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.27 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59023 | — | — | 1 | 7.58 |
| CHEMBL292313 | — | — | 1 | 7.00 |
| CHEMBL291994 | — | — | 1 | 6.52 |
| CHEMBL59338 | — | — | 1 | 6.43 |
| CHEMBL303756 | — | — | 1 | 5.52 |
| CHEMBL61873 | — | — | 1 | 5.52 |
| CHEMBL59248 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59023 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL292313 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL291994 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL59338 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL303756 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL61873 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL59248 | — | IC50 | = | 5000.0 | nM | 5.30 |