Assay Detail
Functional
CHEMBL677187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative logarithm of the molar concentration of an agonist to produce 50% of the maximum effect in guinea pig ileum (mu receptor) determined by Salvadori et al.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.63 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501451 | — | — | 1 | 8.59 |
| CHEMBL458631 | — | — | 1 | 8.57 |
| CHEMBL109390 | — | — | 1 | 7.57 |
| CHEMBL607403 | — | — | 1 | 6.97 |
| CHEMBL2375157 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501451 | — | EC50 | = | 2.57 | nM | 8.59 |
| CHEMBL458631 | — | EC50 | = | 2.692 | nM | 8.57 |
| CHEMBL109390 | — | EC50 | = | 26.92 | nM | 7.57 |
| CHEMBL607403 | — | EC50 | = | 107.15 | nM | 6.97 |
| CHEMBL2375157 | — | EC50 | = | 354.81 | nM | 6.45 |