Assay Detail
Functional
CHEMBL677189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
inhibitory concentration for inhibition of electrically induced smooth muscle contractions of GPI (guinea pig ileum) myenteric-plexus-longitudinal muscle strips.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Deltorphin II analogues with 6-hydroxy-2-aminotetralin-2-carboxylic acid in position 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.65 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296603 | DELTORPHINE II | — | 1 | 6.00 |
| CHEMBL283009 | — | — | 1 | 5.29 |
| CHEMBL280848 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296603 | DELTORPHINE II | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL283009 | — | IC50 | = | 5129.0 | nM | 5.29 |
| CHEMBL280848 | — | IC50 | > | 10000.0 | nM | - |