Assay Detail
Binding
CHEMBL677205
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Inhibition of Epidermal growth factor receptor from A431 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.75 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420624 | — | — | 1 | 10.00 |
| CHEMBL93032 | — | — | 1 | 9.77 |
| CHEMBL102726 | — | — | 1 | 6.50 |
| CHEMBL116308 | — | — | 1 | 6.45 |
| CHEMBL289787 | — | — | 1 | 6.01 |
| CHEMBL117696 | — | — | 1 | - |
| CHEMBL117988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420624 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL93032 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL102726 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL116308 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL289787 | — | IC50 | = | 974.0 | nM | 6.01 |
| CHEMBL117696 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL117988 | — | IC50 | > | 10000.0 | nM | - |